Eight patients with major depression but otherwise healthy underwent radionuclide cardiography before and during nortriptyline treatment. The second examination was performed when the nortriptyline plasma concentration was within the therapeutic range (60-150 micrograms X l-1). Heart rate, arterial
The effects of stress on left ventricular ejection fraction
β Scribed by Marla C. Kiess; Joel E. Dimsdale; Richard H. Moore; Peter Liu; John Newell; Martha Barlai-Kovach; Charles A. Boucher; H. William Strauss
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 715 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0340-6997
No coin nor oath required. For personal study only.
β¦ Synopsis
The left ventricular ejection fraction (EF) was studied in 17 healthy volunteers with a new ambulatory left ventricular function monitor. Heart rate, EF, and blood pressure measurements were made during rest, a psychiatric stress interview, cold exposure, exercise, and eating. An increase in EF was seen during emotional stress (from 0.45 +/- 0.09 to 0.51 +/- 0.13, P less than 0.001). This increase was comparable to that observed during exercise (0.52 +/- 0.14) and eating (0.52 +/- 0.10, P less than 0.001). In contrast, cold exposure caused a decrease in EF (0.43 +/- 0.13, P less than 0.05). These observations demonstrate the powerful hemodynamic consequences of common behaviors as well as the utility and feasibility of studying such behavioral factors in ambulatory subjects.
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