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The Effects of Spermine on the Accessibility of Residues in the M2 Segment of Kir2.1 Channels Expressed in Xenopus Oocytes

✍ Scribed by Hsueh-Kai Chang; Shih-Hao Yeh; Ru-Chi Shieh

Book ID: 110112487
Publisher: Cambridge University Press
Year: 2003
Tongue: English
Weight: 451 KB
Volume: 553
Category: Article
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2003.052845

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## Abstract We previously showed inhibition of K~ir~2 inward rectifier K^+^ channels expressed in __Xenopus__ oocytes by the mitochondrial agents carbonyl cyanide p‐trifluoromethoxyphenylhydrazone (FCCP) and sodium azide. Mutagenesis studies suggested that FCCP may act via phosphatidylinositol 4,5‐