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The Effects of SB 206284A, A Novel Neuronal Calcium-Channel Antagonist, in Models of Cerebral Ischemia

โœ Scribed by Wood, Nigel I.; Barone, Frank C.; Benham, Chris D.; Brown, Tom H.; Campbell, Colin A.; Cooper, David G.; Evans, Martyn L.; Feuerstein, Giora Z.; Hamilton, Tom C.; Harries, Mark H.; King, Penny D.; Meakin, Jackie E.; Murkitt, Karen L.; Patel, Sara R.; Price, William J.; Roberts, Jenny C.; Rothaul, Alan L.; Samson, Nicole A.; Smith, Susan J.; Hunter, A.Jackie


Book ID
110078779
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
496 KB
Volume
17
Category
Article
ISSN
0271-678X

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Effect of a novel calcium antagonist AE0
โœ Katsumi Yamanaga; Yutaka Ohtaki; Takeshi Uchida; Masahiro Watanabe ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 496 KB

We examined the cerebral protective effects of AE0047 employing cerebral ischemia models. In the bilateral carotid arterial occlusion model (BCAO) employing spontaneously hypertensive rats (SHRs), oral administration of AE0047 (0.1-0.3 mg/kg) or nicardipine (3 mg/kg) improved the neurological sympto