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The effects of prenatal exposure to valproic acid on the initial development of serotonergic neurons

✍ Scribed by Oyabu, Akiko; Narita, Masaaki; Tashiro, Yasura

Book ID
120074392
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
947 KB
Volume
31
Category
Article
ISSN
0736-5748

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Pregnant Sprague-Dawley rats were treated with 0, 150 or 200 mg/kg valproic acid by gavage (VPA) on days 7-18 of gestation. These doses produced no maternal toxicity, reproductive effects or effects on offspring growth and survival. Maternal plasma VPA peak levels averaged 99 and 134 micrograms/ml 1