The effects of pinacidil and tolbutamide in feline pial arteries in situ

✍ Scribed by Michael Wahl

• Publisher: Springer
• Year: 1989
• Tongue: English
• Weight: 214 KB
• Volume: 415
• Category: Article
• ISSN: 0031-6768
• DOI: 10.1007/bf00370602

✦ Synopsis

vasomotor effect of the K + channel opener pinacidil was investigated in feline pial arteries of the parietal cortex. Perivascular microapplication (5pl in 40 sec) and an image splitting method for the measure~lent of ~ascular diameter were employed. Pinacidil (10--109 M) induced concentration-dependent dilatations at 10-M and higher concentrations. A _m~ximal dilatation of abo~t 42% was achieved at 10-M, the dilatation at 10-M was reduced to 22%. The sulphonylurea tolbutamide exerted per se no effect in pial arteries but it blocked concentration-dependently the pinacidil induced dilatation. This is consistent with the presence of ATPsensitive K + channels in pial arteries which are closed under resting conditions.