## Objective: To determine the effects of peroxisome proliferator-activated receptor gamma (ppargamma) agonists on interleukin-1 (il-1) induction of nitric oxide (no) and matrix metalloproteinase 13 (mmp-13) in human chondrocytes. ## Methods: Ppargamma expression and synthesis in human chondrocyt
✦ LIBER ✦
The effects of PDTC on interleukin-1β-induced nitric oxide production in chondrocytes
✍ Scribed by Jianxiang Liu; Jingyuan Du; Shuhua Yang; Xiaohua Qiu; Riguang Liu; Chengqing Yi; Xinchun Li
- Publisher
- Springer-Verlag
- Year
- 2009
- Tongue
- Chinese
- Weight
- 390 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0510-9752
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## Abstract ## Objective To investigate the effects of prostaglandin D~2~ (PGD~2~) on interleukin‐1β (IL‐1β)–induced matrix metalloproteinase 1 (MMP‐1) and MMP‐13 expression in human chondrocytes and the signaling pathways involved in these effects. ## Methods Chondrocytes were stimulated with I