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The effects of organic compounds on mutagen- and carcinogen-activating enzymes in vitro

✍ Scribed by Jean J. Bradshaw; Kathryn M. Ivanetich


Book ID
113249263
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
57 KB
Volume
53
Category
Article
ISSN
0165-1161

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## Abstract We investigated the effect of the steroid hormone dehydroepiandrosterone (DHEA) on the hepatic expression and activity of carcinogen‐activating enzymes, the cytochromes P450 (CYP) 1A1, 1A2 and 1B1, in Sprague‐Dawley rats. In animals fed DHEA at 200 or 400 mg/kg body weight every other d