The effects of micromachined surfaces on formation of bonelike tissue on subcutaneous implants as assessed by radiography and computer image processing
✍ Scribed by Chehroudi, B. ;McDonnell, D. ;Brunette, D. M.
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 507 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0021-9304
No coin nor oath required. For personal study only.
✦ Synopsis
Surface topography varies widely among commercially
techniques, and sectioned for histologic observations. The available orthopedic and dental implants. While it is gener-area of the bonelike tissue and its density were calculated ally accepted that the surface topography of an implant in-using National Institutes of Health Image software. Mineralfluences the formation of bone and affects its performance, ization was frequently noted at the interface of some types few systematic studies have dealt with this important feature.
of micromachined surface but rarely on smooth surfaces. The Quantification of the mineralized tissue at the implant inter-presence of bone in histologic sections and areas identified face has typically been attempted using histologic methods or as bone through digital radiography and image processing conventional radiographic procedures. However, histologic correlated strongly. The frequency of bonelike foci formation methods are often technically demanding and time consum-decreased as the depth of the grooves increased. In contrast, ing, whereas conventional radiographic procedures lack res-mineralization occurred more frequently as the depth of the olution and sensitivity to identify small areas of mineraliza-pit increased. In addition, bonelike foci were oriented along tion. The objective of this study was to study systematically the long axis of the grooves. It is thus feasible that the bonelike the effects of micromachined surfaces on bone formation tissue is shaped, directed, or engineered to a predetermined by applying digital radiographic techniques to identify and configuration which is dictated by the surface topography. quantify mineralized tissue. Titanium-coated epoxy replicas
This study indicated that surface topography influences the of 19 different micromachined grooved or pitted surfaces frequency as well as the amount of bone deposited adjacent that ranged between 30 and 120 Ȑm deep, as well as smooth to implants, and mineralized product can be guided by the control surfaces, were implanted percutaneously and fixed surface topography. Moreover, digital radiography and imto the parietal bone of rats. After 8 weeks the implants age processing can be used reliably to identify and quantify and attached tissue were removed and processed for light mineralized tissue at the implant interface. ᭧ 1997 John Wiley & and electron microscopy. A total of 316 implant surfaces Sons, Inc.
were processed, radiographed using conventional and digital *To whom correspondence should be addressed.