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The effects of methylamphetamine on stereotyped behaviour, activity, startle, and orienting responses

โœ Scribed by Robert J. Kirkby; David S. Bell; Alan C. Preston

Publisher
Springer
Year
1972
Tongue
English
Weight
436 KB
Volume
25
Category
Article
ISSN
0033-3158

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โœฆ Synopsis

In two experiments the relationships between methylamphetamine induced stereotyped behaviour and locomotory activity, startle reactivity, and orienting responsiveness were investigated in laboratory rats. Experiment I showed that administration of 5 mg/kg methylamphetamine, compared to 0.5 mg/kg methylamphetamine or saline, resulted in increased stereotypy, increased startle reactivity, and decreased orienting. Experiment IX confirmed that the higher dose of methylamphetamine enhanced startle reactivity, and indicated that concomitant with this, habituation to successive startle stimuli was inhibited. The similarities between stereotypy in the rat and schizophreniform behaviour in the human were discussed.

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