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The effects of local anesthetics on cellular hypoxia-induced gene responses mediated by hypoxia-inducible factor 1

✍ Scribed by Kenichiro Nishi; Kiichi Hirota; Satoshi Takabuchi; Seiko Oda; Kazuhiko Fukuda; Takehiko Adachi; Koh Shingu

Publisher: Springer
Year: 2005
Tongue: English
Weight: 270 KB
Volume: 19
Category: Article
ISSN: 0913-8668
DOI: 10.1007/s00540-004-0271-3

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## Abstract ## BACKGROUND Previous reports indicate that Genistein, a naturally occurring isoflavonoid, exhibits strong antiangiogenic activity. The underlying mechanism of inhibition, however, remains unclear. Among the biologic effects of Genistein are the inhibition of tyrosine kinases and the