The effects of L-dopa on the activity of methionine adenosyltransferase: Relevance to L-dopa therapy and tolerance
โ Scribed by R. Benson; B. Crowell; B. Hill; Kofi Doonquah; C. Charlton
- Publisher
- Springer
- Year
- 1993
- Tongue
- English
- Weight
- 573 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0364-3190
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๐ SIMILAR VOLUMES
Administration of L-dopa (L-3,4-dihydroxyphenylalanine) (200 mg/kg p.o.) to rats produced elevated plasma and muscle concentrations of both L-dopa and 3-O-methyldopa (3-OMD). This effect was potentiated by simultaneous administration of carbidopa (25 mg/kg p.o.). Both L-dopa and 3-OMD accumulated in
Normal rats and those pretreated with reserpine or cr were given L-DOPA alone or with extracerebral decarboxylase inhibitor (Ro 4-4602). l~otility was measured at two different time intervals and the brain levels of noradrenaline (NA) and dopamine (DA) were subsequently determined. No simple correl