## Abstract The influence of age at time of DMBA administration on (l) the histopathogenesis and site of mammary tumor origin and (2) the precancerous nature of DMBAβinduced mammary dysplasias was examined in Lewis rats between 25 and 200 days of age. Rats were killed at various times after carcino
The effects of intermittent progesterone upon tamoxifen inhibition of tumor growth in the 7,12-dimethylbenzanthracene rat mammary tumor model
β Scribed by David FC Gibson; Delinda A. Johnson; Susan M. Langan-Fahey; Mary K. Lababidi; William H. Wolberg; V. Craig Jordan
- Book ID
- 104873573
- Publisher
- Springer US
- Year
- 1993
- Tongue
- English
- Weight
- 373 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0167-6806
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The presence of ER in DMBA-tumors was demonstrated by the use of dextrancharcoal assay, sephadex chromatography, sucrose gradient sedimentation, and organ culture techniques. It was found that tumors have binding sites ranging from 10-" to 10-l' moles/mg protein, and a dissociation constant of ER 10
We examined the effect of consumption of graded increases of dietary fiber (soft white wheat bran) on the development of mammary gland carcinomas in intact female Sprague-Dawley rats during the promotion stage of carcinogenesis, induced with 7,12-dimethylbenz(a)anthracene (DMBA). The percent of rats