The actions of lignocaine and tetrodotoxin (TTX) in a tracheal segment of the cat were tested on secretion of mucus macromolecules radiolabelled with 35S and 3H. Lignocaine, 4.3-43 mM, given into the segment, caused a concentration dependent increase of secretion of 3H-and 35S-labelled macromolecule
The effects of inhalation anaesthetic agents on convulsant (ld-50) doses of local anaesthetics in the rat
β Scribed by John A. Staniweski; J. Antonio Aldrete
- Publisher
- Springer-Verlag
- Year
- 1970
- Tongue
- French
- Weight
- 285 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1496-8975
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## Abstract The cationic local anaesthetics carbocaine and unpercaine were found to increase the fluorideβstimulated adenylate cyclase up to a maximum level; above this maximum level further increases in drug concentration inhibited the enzyme. At concentrations where this activity was stimulated,
delta 9-Tetrahydrocannabinol (2.5-80.0 mg/kg) significantly prolonged the anaesthesia induced by ketamine, pentobarbitone, thiopentone, propanidid, and Alfathesin in a dose-dependent manner. Cannabinol and cannabidiol (both 5.0-80.0 mg/kg) were essentially inactive, except that cannabidiol prolonged