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The effects of FK506, a specific calcineurin inhibitor, on methamphetamine-induced behavioral change and its sensitization in rats

✍ Scribed by Toshio Tsukamoto; Masaomi Iyo; Kunihiko Tani; Yoshimoto Sekine; Kenji Hashimoto; Yutaka Ohashi; Katsuaki Suzuki; Yasuhide Iwata; Norio Mori

Publisher
Springer
Year
2001
Tongue
English
Weight
71 KB
Volume
158
Category
Article
ISSN
0033-3158

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## Abstract The effect of obesity induced by a high‐fat diet on the pharmacokinetics (PK) of nelfinavir (NFV) was investigated, focusing on the change of distribution and elimination caused by dyslipidemia and hepatic steatosis. The plasma unbound fraction (__f__~u~) of NFV in obese rats (0.61Β±0.0