The effects of five weeks treatment with dinitro-o-cresol- or trifluralin-containing pesticides on the germ cells of male mice
✍ Scribed by M. Nehéz; A. Selypes; A. Páldy; E. Mazzag; G. Berencsi; K. Jármay
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- English
- Weight
- 188 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0260-437X
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✦ Synopsis
Abstract
The effects of two pesticides, the insecticide‐herbicide Krezonit E, which contains 50% dinitro‐o‐cresol, and the herbicide Olitref, which contains 26% trifluralin (2,6‐dinitro‐N.N ‐dipropyl‐4‐trifluoromethylaniline), on the gonads and germ cells of male mice were studied. The pesticides were given twice a week for 5 weeks in i.p. doses of 0.6 mg kg^−1^ for Krezonit E and 6.0 mg kg^−1^ for Olitref. These doses are 1% of the i.p. LD~50~. Cytogenic analysis of germ cells carried out from 3 weeks onwards after the last treatment day showed that Olitref significantly increased the frequency of germinal chromosomal abnormalities at 6–7 weeks after treatment. This pesticide increased the frequency of autosomal univalents X/Y separations at meiotic metaphase and multivalent configurations. Krezonit E did not increase significantly the number of chromosomal abnormalities, although there was some increase at 3 weeks, mainly in the form of autosomal univalents.