The effects of different doses of methylpentynol on escape/avoidance conditioning in two strains of rats selectively bred for high and low “emotionality”

✍ Scribed by H. C. Holland; B. D. Gupta

• Publisher: Springer
• Year: 1966
• Tongue: English
• Weight: 362 KB
• Volume: 9
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00406451

✦ Synopsis

Any adequate evaluation of the behavioral effects of a pharmacological compound, particularly where it is assumed to act upon the nervous system, must include consideration of at least three individual factors: (a) the designated activity whereby the effect is to be measured; (b) the dosage function; and (e) individual differences; it is also important to study any interactions they may have with each other. In the present study methylpentynol has been examined for its effects upon the instrumental learning task of escape/avoidance at six dose levels in two strains of rats selectively bred for differences in emotionality. Strain differences are thus substituted for individual differences without sacrifice of the relative invariance which is assumed to characterize repeated measures of the same individual.