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The effects of diabetes and aminoguanidine treatment on endothelial function in a primate model of type 1 diabetes

✍ Scribed by Belinda A. Brooks; Scott Heffernan; Sally Thomson; Susan V. McLennan; Stephen M. Twigg; Dennis K. Yue

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
137 KB
Volume
70
Category
Article
ISSN
0275-2565

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Objectives (a) To study whether there was an increased prevalence of glucose intolerance in the parents of probands with Type 1 diabetes and (b) to look for any possible link between the glucose intolerance in the parents with HLA-DQB1 alleles transmitted in excess to the Type 1 diabetes offspring.

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Background Continuous hyperglycemia is implicated in the pathogenesis of chronic diabetic complications. It is not well known, however, how and to what extent the development of neuropathy is inhibited by blood glucose control in subjects with Type 2 diabetes. We investigated therefore the effects o