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The effects of colchicine and hydroxychloroquine on the cyclo-oxygenases COX-1 and COX-2

✍ Scribed by Eldad Ben-Chetrit; Ruth Fischel; Burkhard Hinz; Micha Levy


Publisher
Springer
Year
2004
Tongue
English
Weight
256 KB
Volume
25
Category
Article
ISSN
0172-8172

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A comparative study of the COX-1 and COX
✍ Shunzhou Wan; Peter V. Coveney πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 968 KB

## Abstract The monotopic proteins COX‐1 and ‐2 in dimeric form bound to lipid bilayer membranes are studied using molecular dynamics simulations within an aqueous environment. The 25‐ns simulations are performed for both isozymes with arachidonic acid bound in the cyclooxygenase sites. The interac