The effects of chlorpromazine on one-trial passive avoidance learning in mice: Further examination of pre- and post-learning administration

✍ Scribed by F. N. Johnson

• Publisher: Springer
• Year: 1970
• Tongue: English
• Weight: 452 KB
• Volume: 18
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00402379

✦ Synopsis

Chlorpromazine in doses of 0.5 mg/kg was administered to mice 0.5, 2, or 10 rain after a one-triM passive avoidance learning experience. The drug produced effects on the magnitude and rate of extinction of the learned response dependent upon the injection time, confirming results contained in a n earlier report. In a second experiment with doses of 2.0 mg/kg, the effects of further injecion times were investigated. The drug had no effect when given 240 rain before learning, but produced maximal blocking of response acquisition when given 120 and 8 rain before learning. Drug injections 6 and 3 rain before learning were suggested as having actions on post-learning memory traces. A distinction was noted between the effects of drug injections 1 and 1.5 rain after learning and this was related to an effect on a rapidly decaying short-term memory trace. Chlorpromazine had no effect when given 20 rain after learning.