The effects of centrally and peripherally acting cholinergic drugs on the short-term performance gradient following passive-avoidance training
✍ Scribed by Allen M. Schneider; Bruce S. Kapp; William M. Sherman
- Publisher
- Springer
- Year
- 1970
- Tongue
- English
- Weight
- 287 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0033-3158
No coin nor oath required. For personal study only.
✦ Synopsis
Rats, injected with physostigmine salicylate, neostigmine methylsulfate, atropine sulfate, atropine methylate, or saline, were trained in a passiveavoidance platform procedure and were tested 5, 15, or 120 see later. In the salinetreated groups step-down latencies increased between the 5-second and 15-second intervals and stabilized between the 15-second and 120-second intervals. Relative to saline controls, the drugs had the following effects: physostigmine decreased test latencies at the 15-and 120-second intervals; atropine sulfate and methylate increased test latencies at the 5-second interval; neostigmine did not modify test latencies at any of the 3 intervals.