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The effects of cardamonin on lipopolysaccharide-induced inflammatory protein production and MAP kinase and NFκB signalling pathways in monocytes/macrophages

✍ Scribed by S Hatziieremia; A I Gray; V A Ferro; A Paul; R Plevin

Book ID: 110009245
Publisher: Nature Publishing Group
Year: 2009
Tongue: English
Weight: 223 KB
Volume: 149
Category: Article
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0706856

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## Abstract Blood vessel injury results in limited oxygen tension and diffusion leading to hypoxia, increased anaerobic metabolism, and elevated production of acidic metabolites that cannot be easily removed due to the reduced blood flow. Therefore, an acidic extracellular pH occurs in the local mi