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The Effects of Caloric Restriction on Health and Longevity

✍ Scribed by Jacqueline L. Green; Fadi J. Sawaya; Allen L. Dollar


Book ID
107556021
Publisher
Springer
Year
2011
Tongue
English
Weight
123 KB
Volume
13
Category
Article
ISSN
1092-8464

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## Abstract Caloric restriction (CR), which improves health and increases longevity, was studied as a therapy in a hexosaminidase Ξ² knockout mouse model of Sandhoff disease (SD), an incurable neurodegenerative disease involving accumulation of brain ganglioside GM2 and asialo‐GM2 (GA2). Adult mice

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## Abstract Research on caloric restriction for longevity (CRL) has generated hundreds of articles on the physiology of food deprivation, yet almost no data on consequences in other domains. The first paper in this series outlined the generally positive physical effects of CRL; the second analyses