In vivo-in vitro correlation (IVIVC) is an effective tool to predict absorption behavior of active substances from pharmaceutical dosage forms. The model for immediate release dosage form containing amoxicillin was used in the presented study to check if the calculation method of absorption profiles
The effects of averaging on accuracy of IVIVC model predictions
โ Scribed by Clare Gaynor; Adrian Dunne; John Davis
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 298 KB
- Volume
- 98
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
โฆ Synopsis
When using the method of deconvolution to establish an IVIVC model, the choice of whether or not to average the data before analysis is a crucial one. Averaging the data leads to a loss of information and current advice on best practise suggests that deconvolution take place at the individual subject level. This study compares each approach and concludes that averaging has a detrimental effect on the accuracy of predictions produced.
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