The effects of arotinoids on rat mammary carcinogenesis

✍ Scribed by Hans-Rudolf Hartmann; Werner Bollag

• Book ID: 104687313
• Publisher: Springer
• Year: 1985
• Tongue: English
• Weight: 214 KB
• Volume: 15
• Category: Article
• ISSN: 0344-5704
• DOI: 10.1007/bf00257524

✦ Synopsis

The influence of two retinoids, Ro 13-6298, an arotinoid ethyl ester, and Ro 15-1570, an arotinoid ethyl sulfone, on rat mammary carcinogenesis was investigated. Mammary carcinomas were induced by oral administration of 15 mg dimethylbenz(a)anthracene (DMBA) to 50-day-old female Sprague-Dawley rats. Oral administration of the two retinoids significantly inhibited the development of tumors. The number and volume of mammary neoplasms were influenced in a dose-dependent manner.