Despite the extremely widespread use of antipsychotic medications, there is little evidence from the surveys conducted to date, that this class of psychoactive medications is significantly implicated in vehicular crashes or deaths. In five major surveys of vehicular fatalities, in which drug and alc
The effects of alcohol on the cognitive function of males and females and on skills relating to car driving
β Scribed by J. S. Kerr; N. Sherwood; I. Hindmarch; J. Z. Bhatti; G. A. Starmer; D. J. Mascord
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 845 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0885-6222
No coin nor oath required. For personal study only.
β¦ Synopsis
Nine male and nine female subjects received one of four doses of alcohol (0.25,0.5, 0.75 or 1 g per kg of bodyweight for male subjects: females received 92% of these values) or placebo. Similar blood alcohol concentrations (BAC) for males and females were reached. Subjects were then tested on two batteries of psychological tests related to skills involved in driving. These included psychomotor, cognitive and subjective assessment tasks. The results showed a linear increase in the disruption of performance with dose for many of the tests, particularly those involving psychomotor function. In addition it was demonstrated that on certain tasks males were affected more by alcohol than females. It is concluded that moderate doses of alcohol (resulting in BACs of 0.05 to 0.08 g/100ml) can produce significant deficits in perceptual and motor skills related to driving a vehicle.
π SIMILAR VOLUMES
Fourteen normal female volunteers were allocated to either a 'skilled' or a control group. All subjects received acute doses of 0.8 g/ kg absolute alcohol or placebo equivalent. Performance on a number of tests of cognitive functioning and perceptual-motor skill was recorded commencing 30 min follow
## Objective The STISIM driving simulator is widely used. To enhance its usefulness in pharmacological research, a calibration study was performed to test a standardized highway driving test scenario after administration of three different dosages of alcohol and placebo. ## Methods Twentyβseven h
Ten healthy female volunteers received single doses of amitriptyline 50 mg (AMI); mianserin 20 mg (MIA); trazodone 50mg (TRA); paroxetine 30mg (PAR) and placebo (PLA), with or without a 'social' dose of alcohol (ALC) in a double-blind, balanced crossover study where each subject acted as her own con
## Abstract ## Objective To assess the effects of paroxetine and mirtazapine on psychometric performance related to car driving, including an onβtheβroad test of BRT. ## Method In a 4βway, double blind randomised crossover study, 12 healthy volunteers received paroxetine 20βmg mane, mirtazapine