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The effects of acute falciparum malaria on the disposition of caffeine and the comparison of saliva and plasma-derived pharmacokinetic parameters in adult Nigerians

โœ Scribed by O. O. Akinyinka; A. Sowunmi; R. Honeywell; A. G. Renwick

Publisher
Springer
Year
2000
Tongue
English
Weight
144 KB
Volume
56
Category
Article
ISSN
0031-6970

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โœ C.A. Okonkwo; H.A.B. Coker; P.U. Agomo; J.A. Ogunbanwo; A.G. Mafe; C.O. Agomo; B ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 736 KB

Chlorpheniramine (Cl'), a histamine Hi-receptor antagonist, enhances the efficacy of chloroquine (CQ) in acute uncomplicated falciparum malaria. The effects of this combination therapy on the pharmacokinetic disposition of CQ is, however, unpredictable. A standard treatment with 25 mg CQ base per kg