The effects of acute doses of dothiepin (25, 50, and 75 mg) versus placebo on psychomotor performance and cognitive function
✍ Scribed by C. Dal Pozzo; J. S. Kerr; C. Balguranidis; J. S. Yoon; I. Hindmarch
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 160 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0885-6222
No coin nor oath required. For personal study only.
✦ Synopsis
Sixteen healthy volunteers received dothiepin 25 mg, 50 mg, 75 mg and placebo in a double-blind crossover study. Each subject received the four treatments once, with a 6-day washout period between test days. On each occasion psychomotor performance and cognitive function were measured 30 min before dosing and 1, 2, 4, 6 and 8 h after drug administration. The test battery comprised: Critical Flicker Fusion, Choice Reaction Time, Continuous Tracking and Short Term Memory. Subjective ratings of sedation were measured using Line Analogue Rating Scales. Dothiepin at the subtherapeutic dose of 75 mg was shown to produce statistically signi®cant impairment ( p `0Á05) on several of the variables investigated. These included CFF at the 2-and 4-h test points, TRT at the 2-h test point and LARS at the 2-and 4-h test points. Lower doses also produced impairment of cognitive function and psychomotor performance as measured by the present test battery.