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The effects of accumulation of an environmentally relevant polychlorinated biphenyl mixture on cytochrome P450 and P-glycoprotein expressions in fetuses and pregnant rats

✍ Scribed by Patrizia Bonfanti; Anita Colombo; Sara Villa; Francesca Comelli; Barbara Costa; Angela Santagostino


Book ID
116361144
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
346 KB
Volume
75
Category
Article
ISSN
0045-6535

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## Pulmonary cytochrome P450 monooxygenases metabolize xenobiotic chemicals, including those found in environmental tobacco smoke (ETS). Exposure to ETS beginning at birth has been shown to induce the P450 CYP1A1 by seven days of life. The effects of perinatal exposure to ETS of the rat lung on the