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The effects of a single neonatally induced convulsion on spatial navigation, locomotor activity and convulsion susceptibility in the adult rat

✍ Scribed by Rick A. Kornelsen; Francis Boon; L. Stan Leung; D. Peter Cain


Book ID
113128023
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
415 KB
Volume
706
Category
Article
ISSN
0006-8993

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In a series of experiments, rats received the noncompetitive N-methyl-B-aspartate (NMDA) antagonist MK-801 and measures were made of motor behavior, spatial navigation in a swimming pool, and electroencephalographic (EEG) activity. High doses (0.25-10 mg/kg IV) produced somnolence and akinesia, impa