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The effects of 2-substituted oestrogen sulphamates on the growth of prostate and ovarian cancer cells

โœ Scribed by Joanna M. Day; Simon P. Newman; Alexander Comninos; Claire Solomon; Atul Purohit; Matthew P. Leese; Barry V.L. Potter; Michael J. Reed

Book ID
117668490
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
385 KB
Volume
84
Category
Article
ISSN
0960-0760

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2-Methoxyoestrogens are emerging as a new class of drug that can inhibit tumour growth and angiogenesis. As sulphamoylation of oestrogens enhances their potency and bioavailability we have synthesized 2-methoxyoestrone-3-O-sulphamate (2-MeOEMATE) and compared its ability to inhibit the proliferation