Pre-clinical data indicate that retinoid/interferon combinations have significant activity in modulating malignant cell growth, differentiation and programmed cell death in different hematologic and solid tumor systems . Clinically, the combination of 13-cis retinoic acid (13cRA) and interferon-a (I
The Effects of 13-cis Retinoic Acid on Squamous Cell Carcinoma Proliferation and Adhesion to Extracellular Matrix Proteins
β Scribed by Matthew T. Speyer; Jon A. Jackson; Brian B. Burkey
- Book ID
- 110079267
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 591 KB
- Volume
- 107
- Category
- Article
- ISSN
- 0023-852X
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## Abstract ## Background. We have previously conducted phase II trials with a combination of 13β__cis__βretinoic acid (13βcRA), interferonβΞ±2a (IFNβΞ±2a), and Ξ±βtocopherol (Ξ±βTF) in patients with advanced oral premalignant lesions and locally advanced head and neck cancer in the adjuvant settings
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