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The effect on cardiac muscle of two drugs related to amiodarone, L8040 and L8462

✍ Scribed by E.M. Vaughan Williams; P. Polster


Book ID
118321418
Publisher
Elsevier Science
Year
1974
Tongue
English
Weight
511 KB
Volume
25
Category
Article
ISSN
0014-2999

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Administration of L-dopa (L-3,4-dihydroxyphenylalanine) (200 mg/kg p.o.) to rats produced elevated plasma and muscle concentrations of both L-dopa and 3-O-methyldopa (3-OMD). This effect was potentiated by simultaneous administration of carbidopa (25 mg/kg p.o.). Both L-dopa and 3-OMD accumulated in