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The effect ofN-alkyloxycarbonyl group on the anticonvulsant activities ofN-alkyloxycarbonyl-α-aminoglutarimides

✍ Scribed by Kichun Son; Kyungim Jung; Minjeong Kim; Jaewon Lee; Jongwon Choi; Eung-seok Lee; Minsoo Park


Publisher
Springer
Year
1998
Tongue
English
Weight
439 KB
Volume
21
Category
Article
ISSN
0253-6269

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The kinetic and mechanistic effects of substitution in the leaving group of N-acylimidazoles in Ͱ-chymotrypsin-catalyzed hydrolysis reactions have been investigated. The values of k 2 /K m have been determined for acylation of the enzyme by a series of N-(3,3-dimethylbutyryl)-4(5)-substituted imidaz