The effect of vagotomy and pyloroplasty on colorectal tumor induction in the rat

✍ Scribed by Dr. Richard L. Nelson; Susan Briley; Octavio P. Vaz; Hercand Abcarian

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 906 KB
• Volume: 51
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/jso.2930510416

✦ Synopsis

Abstract

Epidemiologic studies have suggested that vagotomy increases subsequent colorectal cancer risk. This hypothesis was investigated in the rat 1,2 dimethylhydrazine (DMH) colorectal carcinogenesis model. Eighty‐five rats were divided into four groups having either truncal vagotomy and Heineke‐Mickulicz pyloroplasty, pyloroplasty alone, laparotomy alone, and anesthesia alone. After recovery from the procedures, colon tumors were induced with five injections of DMH. Results of carcinogenesis show a trend towards increased incidence and yield of colorectal and duodenal tumors after vagotomy, though this was not statistically significant, perhaps because the high postoperative mortality from vagotomy diminished the power of the Study. © 1992 Wiley‐Liss, Inc.