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The effect of tumor promoters and antagonists on in vitro directional migration of 10T1/2 mouse embryo cells

✍ Scribed by Hendrik Verschueren

Publisher
Springer
Year
1985
Tongue
English
Weight
693 KB
Volume
1
Category
Article
ISSN
0742-2091

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✦ Synopsis

In vitro directional migration of l OT1/2fibroblasts is partially inhibited by TPA but not by its non-promoting analogues. Other tumor promoters, e.g., phenobarbital, saccharin, and benzoylperoxide had no measurable effect when added in concentrations known to affect in vitro two-step transformation or intercellular communication. Inhibitors of in vitro transformation do not affect migration, except for dexamethasone, which inhibited it. Hence, there is no evidence for a general correlation between tumor promoting potential and inhibition o fin vitro directional migration.

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