The ability of recombinant human tumor necrosis factor (rH-TNF-alpha) to induce regression of sarcoma 180 in vivo was evaluated. The tumor was cured by TNF in the course of 4 weeks. TNF inhibited proliferation of sarcoma 180 cells in vitro, which suggests a direct effect of TNF on tumor cells in viv
The effect of tumor necrosis factor on normal human hematopoietic progenitors
β Scribed by Sherry L. Abboud; Stanton L. Gerson; Nathan A. Berger
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 583 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0008-543X
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Erythroid progenitors from normal human marrow were purified by a two-step immune panning method permitting both the enrichment of erythroid progenitors (plating efficency up to 10%) and the separation of CFU-E from BFU-E. The purified erythroid progenitors wcre grown in serum-replaced conditions; i
## Abstract The mechanism of growth inhibition mediated by tumor necrosis factor (TNF) is unclear. Since recent data strongly suggested that generation of superoxide is a key step in cytotoxicity of TNF, we reasoned that cells expressing high levels of enzymes that degrade superoxide radicals would