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The effect of trypsin on membrane transport of non-electrolytes

✍ Scribed by Min-Fu Tsan; Rebekah A. Taube; Richard D. Berlin

Publisher
John Wiley and Sons
Year
1973
Tongue
English
Weight
512 KB
Volume
81
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

Trypsinization of alveolar macrophages depresses lysine transport but has no effect on nucleoside transport. The depression of the initial rate of lysine transport is due to a decreased rate of exchange diffusion presumably secondary to lowered intracellular pools of amino acids. It is shown directly that trypsinization accelerates the efflux of amino acids but not certain other metabolites, and reduces the capacity of the cell to concentrate amino acids.

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