Adenomatous polyposis coli, protein kina
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William R. Waddell; Roger L. Miesfeld
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Article
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1995
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John Wiley and Sons
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English
β 528 KB
A putative explanation of the effect of sulindac on adenomatous colon and duodenal polyps from clinical observations and related in vitro experiments is presented. In cells with mutant APC genes, persistent high prostaglandin content of polyps leads to desensitization, downregulation of adenylate cy