The effect of transforming growth factor-β1 on nasopharyngeal carcinoma cells: insensitive to cell growth but functional to TGF-β/Smad pathway
✍ Scribed by Jian Xiao, Qi Xiang, Ye-Chen Xiao…
- Book ID
- 120698607
- Publisher
- BioMed Central
- Year
- 2010
- Tongue
- English
- Weight
- 996 KB
- Volume
- 29
- Category
- Article
- ISSN
- 1756-9966
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Transforming growth factor beta (TGF-beta) exerts an inhibitory effect on the growth of most epithelial cell types, and the loss of responsiveness to this growth inhibition has been implicated in the development of a variety of human cancers. The genetic alteration of TGF-beta receptors is known to
A panel of 6 human glioma cell lines was examined for TGF-1 responsiveness. U-178 MG and U-251 MG AgCl1 were significantly inhibited by TGF-1, while U-343 MGa 31L and U-343 MGa 35L were potently stimulated to proliferate. TGF-1 induced endogenous PAI-1 protein synthesis, Smad binding element/(CAG