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The effect of thiodiglycol and dithiothreitol on the alkaline hydrolysis products of certain amino acid phenylthiohydantoins

โœ Scribed by J.R. Jabusch; D.C. Parmelee; H.F. Deutsch

Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
464 KB
Volume
91
Category
Article
ISSN
0003-2697

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โœฆ Synopsis

The thiazolinone and phenylthiohydantoin derivatives of most amino acids can be hydrolyzed with alkaline dithionite to generate the free amino acid. The acidification of this hydrolysate with 3 N HCl containing thiodiglycol leads in the case of glutamic acid, glutamine, aspartic acid, asparagine, and S-carboxy-methylcysteine to the generation of ninhydrin-reacting components having the chromatographic properties of other amino acids. The use of dithiothreitol instead of thiodiglycol appears to be more satisfactory in most instances.

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