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The effect of the trichloroethylene metabolites trichloroacetate and dichloroacetate on peroxisome proliferation and DNA synthesis in cultured human hepatocytes

✍ Scribed by J.E. Walgren; D.T. Kurtz; J.M. McMillan


Book ID
110252581
Publisher
Springer
Year
2000
Tongue
English
Weight
250 KB
Volume
16
Category
Article
ISSN
0742-2091

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The effect of dichloroacetic acid and tr
✍ Rongrong Ge; Siming Yang; Paula M. Kramer; Lianhui Tao; Michael A. Pereira πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 181 KB

## Abstract The chlorine disinfection by‐products, dichloroacetic acid (DCA) and trichloroacetic acid (TCA), are carcinogenic in mouse liver. We have previously reported that DCA and TCA induced DNA hypomethylation in mouse liver. In the present study, we determined the temporal association for DNA