The effect of the mGlu5 receptor antagonist MPEP in rodent tests of anxiety and cognition: a comparison
✍ Scribed by Theresa M. Ballard; Marie L. Woolley; Eric Prinssen; Jörg Huwyler; Richard Porter; Will Spooren
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 227 KB
- Volume
- 179
- Category
- Article
- ISSN
- 0033-3158
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## Abstract This study was designed to test whether chronic treatment with the metabotropic glutamate receptor 5 (mGlu5R) antagonist MPEP showed antiparkinsonian effects in rats unilaterally lesioned with 6‐hydroxydopamine (6‐OHDA) (a “classic” model of Parkinson's disease, PD), and to evaluate whe
The effects of three 5HT3 receptor antagonists: BRL 43964 (0.1 and 1 mg/kg, oral), GR 38032F (0.1 and 1 mg/kg, oral), and zacopride (0.01, 0.1 and 1 mg/kg, IP) were examined in low light test conditions of the social interaction test. None of the three 5HT3 receptor antagonists had a significant eff