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The effect of the fiber components cellulose and lignin on experimental colon neoplasia

✍ Scribed by David A. Sloan; David M. Fleiszer; Geoffrey K. Richards; David Murray; Rea A. Brown

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
586 KB
Volume
52
Category
Article
ISSN
0022-4790

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✦ Synopsis

Sixty Sprague-Dawley rats were pair-fed one of three nutritionally identical diets. One diet contained "low-fiber" (3.8% crude fiber); the others contained "high fiber" (28.7% crude fiber) composed of either cellulose or lignin. Although both "high fiber" diets had similar stool bulking effects, only the cellulose diet was associated with a reduction in 1,2-dimethylhydrazine (DMH)-induced colon neoplasms. The cellulose diet was also associated with distinct changes in the gut bacterial profile and with a lowered serum cholesterol.

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## Abstract The existence of lignin in lignocellulosic fibers increases the loss in breaking tenacity and elongation of fibers when they are exposed to heat and light. Delignification by sulfonation helps to remove some of the lignin from the fibers without affecting the breaking tenacity. The deli