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The effect of the enantiomers of 3-PPP on conditioned avoidance responding in the rat

✍ Scribed by David Clark; Arvid Carlsson; Stephan Hjorth; Jörgen Engel; Per Lindberg

Publisher
Springer
Year
1983
Tongue
English
Weight
499 KB
Volume
81
Category
Article
ISSN
0033-3158

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✦ Synopsis

The effects of the enantiomers of 3-PPP on the maintenance of conditioned avoidance responding (CAR) were studied. The weak classical dopamine (DA) agonist (+)-3-PPP failed to interfere with CAR at any dose tested (0.8-13.6 mg/kg). Low doses of the drug produced sedation, while high doses produced behavioural stimulation. (-)-3-PPP, which acts as an antagonist on postsynaptic and as an agonist on autoreceptor DA sites, reduced avoidance with no effect on escape behaviour (6.8-13.6 mg/kg). However, this reduction of CAR occurred at doses much higher than those previously demonstrated to inhibit locomotor activity. This profile is discussed in relation to the behavioural effects of classical postsynaptic DA receptor antagonists.

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✍ S. Ahlenius; T. Archer; B. Tandberg; V. Hillegaart 📂 Article 📅 1984 🏛 Springer 🌐 English ⚖ 575 KB

The administration of (-)3-(3-hydroxyphenyl)-N-n-propylpiperidine (3-PPP) was found to partially, but significantly, suppress the acquisition (4-8 mg/kg IP) and performance (8-16 mg/kg IP) of a conditioned avoidance response (CAR) in male Sprague-Dawley rats. All statistically significant effects we