✦ LIBER ✦
The Effect of the Carbon Ligand on the Reaction of Organozinc Reagents in the Synthesis of Substituted 2,5-Dihydrofurans: A Rare Example of An Uncatalysed Allylic-Substitution Reaction Involving Alkyl Zinc Halides
✍ Scribed by Mark Woods; Nuno Monteiro; Geneviève Balme
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 369 KB
- Volume
- 2000
- Category
- Article
- ISSN
- 1434-193X
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✦ Synopsis
Organozinc halides derived from Grignard reagents behave differently in their reaction with ethyl (±)-(2RS,3SR)-tetrahydro-4-methylene-2-phenyl-3-(phenylsulfonyl)furan-3-carboxylate (3) according to the hybridisation of the carbon ligand. During the development of short multi-component reactions for the synthesis of diverse functionalized ethyl 2,5dihydrofuran-3-carboxylates it was discovered that aryl and