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THE EFFECT OF THE ANTIPSORIATIC DRUG METABOLITE ETRETIN (Ro 10-1670) ON UVB IRRADIATION INDUCED CHANGES IN THE METABOLISM OF ARACHIDONIC ACID IN HUMAN KERATINOCYTES IN CULTURE

✍ Scribed by Kari Punnonen; Tapio Puustinen; Christer T. Jansean


Book ID
114894862
Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
481 KB
Volume
44
Category
Article
ISSN
0031-8655

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The antipsoriatic drug metabolite etreti
✍ K. Punnonen; T. Puustinen; C. T. JansΓ©n πŸ“‚ Article πŸ“… 1988 πŸ› Springer-Verlag 🌐 English βš– 535 KB

We have studied the effect of etretin (Ro 10-1670), the active metabolite of the widely used antipsoriatic drug etretinate (Ro 10-9359), on the incorporation and release of arachidonic acid in human skin keratinocytes. During 24-h culture, radioactive 14C-arachidonic acid was avidly incorporated int