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The Effect of Temperature and pH on the Solubility of Quinolone Compounds: Estimation of Heat of Fusion

โœ Scribed by Xuanqiang Yu; Gail L. Zipp; G. W. Ray Davidson III


Book ID
110379377
Publisher
Springer US
Year
1994
Tongue
English
Weight
662 KB
Volume
11
Category
Article
ISSN
0724-8741

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We have examined the effect of pH and temperature on the solubility of 3-(4-heptylbenzoyl) benzoic acid (1), a surface active carboxylic acid with a pKa of 4.83 and a critical micelle concentration (cmc) of 4 X 10(-4) M. Our results show that below a pH of 7.0 and a temperature of 50 degrees C, the