The effect of tamoxifen therapy on thyroid function tests
โ Scribed by Derek Gordon; Graham H. Beastall; Colin S. McArdle; John A. Thomson
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 296 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Background: Endocrine cells of the prostate secrete thyrotropin (tsh)-releasing hormone (trh), trh- and tsh-like peptides, and growth factors. propylthiouracil- and methimazole-induced hypothyroidism increased prostatic levels of trh in rats as in hypothalamus, whereas thyroxine (t4) replacement
The effects of single doses of tamoxifen (TAM; 0.5-5 mg/kg, i.v.) and chronic pretreatment with TAM (0.1-5.0 mg/kg/day, i.p. for 7 consecutive days) on letrozole (0.5 mg/kg, i.v.) pharmacokinetics were evaluated in female Sprague-Dawley rats. The plasma concentration-time profiles of letrozole (0.1-