The effect of sulphonylurea on the in vivo tissue uptake of glucose in normal rats

✍ Scribed by A. D. Mooradian

• Publisher: Springer
• Year: 1987
• Tongue: English
• Weight: 176 KB
• Volume: 30
• Category: Article
• ISSN: 0012-186X
• DOI: 10.1007/bf00274583

✦ Synopsis

To evaluate the effect of sulphonylurea on in vivo tissue uptake of glucose, the arterial injection tissue-sampling technique of Oldendorf was used to measure the glucose uptake of brain; liver; subcutaneous fat; and of three skeletal muscles, the masseter, femoris and soleus. Rats gavaged with glipizide 5 mg/kg daily for 5 days were compared to vehicle-treated rats. The serum glucose levels at the time of the experiment were identical in the two groups (10.36 +/- 0.42 mmol/l vs 10.38 +/- 0.36 mmol/l). Glipizide treatment did not result in an increase in glucose uptake by the various tissues studied. It is concluded that, under physiological conditions in non-fasted rats, sulphonylureas do not significantly alter tissue uptake of glucose.