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The effect of sulfation of alginate hydrogels on the specific binding and controlled release of heparin-binding proteins

โœ Scribed by Inbar Freeman; Alon Kedem; Smadar Cohen

Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
1007 KB
Volume
29
Category
Article
ISSN
0142-9612

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## Abstract Effects of ligand binding on protein dynamics are studied via molecular dynamics (MD) simulations on two different enzymes, dihydrofolate reductase (DHFR) and triosephosphate isomerase (TIM), in their unliganded (free) and liganded states. Domain motions in MD trajectories are analyzed